MALAT1

1. 본문

MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is a long non-coding RNA (lncRNA) also known as NEAT2 (Nuclear-Enriched Abundant Transcript 2). It is highly conserved among mammals and is found in the cell nucleus.

Here's a breakdown of what MALAT1 is and its functions:

• lncRNA: MALAT1 is a type of RNA that doesn't code for proteins. Instead, it plays a regulatory role in various cellular processes.
• Highly Conserved: The sequence of MALAT1 is very similar across different mammalian species, suggesting that it has important biological functions.
• Nuclear Localization: MALAT1 is primarily found in the nucleus of cells.
• Gene Regulation: It is known to regulate the expression of genes, particularly those associated with metastasis. It can act at both the transcriptional (affecting how genes are transcribed into RNA) and post-transcriptional levels (affecting RNA after it's made). Proposed mechanisms include regulating splicing.
• Gene ID and Location: MALAT1, with gene ID: 378938 is located on chromosome 11q13.
• Other names: MALAT1, metastasis associated lung adenocarcinoma transcript 1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853.

• Cancer Metastasis: MALAT1 was initially discovered for its association with metastasis, particularly in early-stage non-small cell lung cancer (NSCLC). It is often upregulated in various tumor types and has been shown to influence tumor cell proliferation, migration, invasion, and apoptosis.
• Cell Motility: MALAT1 positively regulates cell motility.
• Regulation of Gene Expression: MALAT1 can form molecular scaffolds and acts as a transcriptional regulator for many genes including ones linked to cancer metastasis and cell migration.
• Cell Cycle Regulation: It's also been implicated in regulating the cell cycle.
• Sex determination: MALAT 1 may play a role in temperature-dependent sex determination.