노빌레틴

3. 약리 작용

in vitro 및 동물 실험에서 항염증 및 종양의 침윤, 확산, 전이를 억제하고,^[14][15][16] 피부염 및 간염을 억제하는 작용이 나타났다.^[17][18] 연골 분해 억제 효과도 보고되었다.^[19] 배양 해마 세포에서 AMPA 수용체를 활성화시켜 뉴런의 장기강화를 촉진하는 것으로 나타났다.^[20] 이는 치매 예방에 효과가 있을 수 있음을 시사한다.

세포 배양에서 AMPA 수용체 활성 및 장기 기억 증강을 증가시키는 것으로 나타났다.^[3] 아토르바스타틴과의 병용은 결장암에 대한 시너지 효과를 보였다.^[4] 또한, 삼중 음성 유방암에서 IκB/NF-κB 신호 전달 억제를 통해 항종양 효능을 향상시킨다.^[6][7][8]

3. 1. 항염증 작용

3. 2. 항암 작용

3. 3. 연골 보호

3. 4. 신경 세포 활성화

3. 5. 기타 작용

참조

_[1] 논문 Mechanism of Neurotrophic Action of Nobiletin in PC12D Cells
_[2] 논문 Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products http://www.oarsijour[...] 2011-12-27
_[3] 논문 Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus 2008
_[4] 논문 Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis 2017-04-01
_[5] 논문 Flavonoid composition of fruit tissues of citrus species 2006
_[6] 논문 The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice 2001
_[7] 논문 Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells 2002
_[8] 논문 Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation 2004
_[9] 논문 Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes ''in vivo'' and ''in vitro'' 2004
_[10] 논문 Hepatoprotective effects of flavonoids from shekwasha (''Citrus depressa'') against D-galactosamine-induced liver injury in rats 2010
_[11] 논문 Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products http://www.oarsijour[...] 2011-12-27
_[12] 논문 Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus 2008
_[13] 논문 Flavonoid composition of fruit tissues of citrus species 2006
_[14] 논문 The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice 2001
_[15] 논문 Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells 2002
_[16] 논문 Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation 2004
_[17] 논문 Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes ''in vivo'' and ''in vitro'' 2004
_[18] 논문 Hepatoprotective effects of flavonoids from shekwasha (''Citrus depressa'') against D-galactosamine-induced liver injury in rats 2010
_[19] 논문 Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products http://www.oarsijour[...] 2011-12-27
_[20] 논문 Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus 2008