이독성

3. 이독성 물질

아미노글리코사이드계 항생제, 루우프이뇨제, 백금 기반 화학 요법 물질 등 다양한 종류의 약물과 수은, 납 등의 중금속, 유기 용제와 같은 환경적 요인이 이독성을 유발할 수 있다.^[69] 아스피린과 같은 살리실산염이나 발기 부전 치료제 또한 이독성을 유발할 수 있다고 알려져 있다.^[69][74]

미국임상종양학회(American Society of Clinical Oncology, ASCO)에서는 시스플라틴에 의한 이독성을 막기 위해 아미포스틴 복용을 시험적으로 사용했으나, 정규 사용을 추천하지 않는다.^[73]

소음과 용매에 모두 노출되는 대표적인 활동은 다음과 같다.^[48]

3. 1. 항생제

3. 2. 루프 이뇨제

3. 3. 화학 요법 물질

3. 4. 소독제 및 방부제

3. 5. 기타 약물

3. 6. 환경 및 작업장 내 이독성 물질

4. 이독성 모니터링 및 관리

이독성 모니터링 및 관리를 위한 국제적으로 통용되는 단일 프로토콜은 없지만, 여러 가이드라인이 발표되었다.^[10][11]

4. 1. 청각 검사

4. 1. 1. 유의미한 변화 기준

• 어떤 검사 주파수에서든 순음 역치가 20dB 이상 감소
• 인접한 두 주파수에서 10dB 이상 감소
• 이전에 반응이 있었던 세 개의 연속적인 검사 주파수에서 반응이 없는 경우

4. 2. 전정 검사

5. 치료

특별한 치료법은 없으나, 원인 물질 노출을 즉각 중단하여 증상을 완화할 수 있다면 그렇게 하는 것이 적절하다.^[69]

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