(E)-4-하이드록시-3-메틸뷰트-2-엔일 피로인산

3. 생물학적 의의 및 면역 반응

HMB-PP는 사람 결핵균을 포함한 대부분의 병원균 및 말라리아 원충에 필수적인 대사 물질이지만, 사람에게는 존재하지 않아 면역 반응의 표적이 된다^[7]. HMB-PP는 사람의 Vγ9/Vδ2 T 세포에 대해 강력한 활성을 가지는 포스포항원으로, IPP나 알킬아민과 같은 자연 화합물보다 훨씬 강력하다^[8].

3. 1. Vγ9/Vδ2 T 세포 활성화

참조

_[1] 논문 The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants
_[2] 논문 Synthesis of (E)-4-hydroxydimethylallyl diphosphate. An intermediate in the methyl erythritol phosphate branch of the isoprenoid pathway
_[3] 논문 Biosynthesis of isoprenoids via the non-mevalonate pathway
_[4] 논문 Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor Periplakin 2015
_[5] 논문 The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants
_[6] 논문 Synthesis of (E)-4-hydroxydimethylallyl diphosphate. An intermediate in the methyl erythritol phosphate branch of the isoprenoid pathway
_[7] 논문 Biosynthesis of isoprenoids via the non-mevalonate pathway
_[8] 논문 Microbial isoprenoid biosynthesis and human γδ T cell activation
_[9] 논문 The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants
_[10] 논문 Synthesis of (E)-4-hydroxydimethylallyl diphosphate. An intermediate in the methyl erythritol phosphate branch of the isoprenoid pathway
_[11] 논문 Biosynthesis of isoprenoids via the non-mevalonate pathway https://archive.org/[...]
_[12] 논문 Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor Periplakin 2015