방향족 아미노산

3. 생화학

방향족 아미노산은 체내에서 다양한 생리 활성 물질의 전구체로 사용된다. 페닐알라닌은 티로신의 전구체이며, 티로신은 다시 L-도파, 도파민, 노르에피네프린, 에피네프린, 티록신의 전구체이다.^[17] 트립토판은 세로토닌, 트립타민, 옥신, 키뉴레닌, 멜라토닌 등의 전구체이다.^[17][6] 히스티딘은 히스타민의 전구체이다.

3. 1. 생합성 경로

3. 1. 1. 시킴산 경로

3. 1. 2. 방향족 아미노산의 예

3. 2. 전구체로서의 방향족 아미노산

3. 3. 영양적 요구

4. 혈액뇌관문(BBB) 통과

방향족 아미노산(AAA)과 분지쇄 아미노산(BCAA)은 혈액뇌관문을 통과할 때 같은 수송 담체를 사용한다.

이 때문에 혈중 BCAA/AAA 비율(피셔 비)이 어떤 질환 등으로 인해 균형을 크게 잃으면 뇌 기능에 영향을 줄 수 있다.

참조

_[1] 논문 Protein tryptophan accessibility studied by fluorescence quenching 2002-05-01
_[2] 논문 Biological Macromolecules: UV‐visible Spectrophotometry http://www.life.illi[...] John Wiley & Sons Ltd 2001-04
_[3] 웹사이트 Peptide and Amino Acid Quantification Using UV Fluorescence in Synergy HT Multi-Mode Microplate Reader {{!}} April 18, 2003 https://www.biotek.c[...] 2020-03-23
_[4] 논문 Structures of single-layer β-sheet proteins evolved from β-hairpin repeats 2019-09
_[5] 논문 Aromatic cluster mutations produce focal modulations of β-sheet structure 2015-05
_[6] 논문 Editorial: Aromatic Amino Acid Metabolism 2019-04-10
_[7] 논문 The Biosynthetic Pathways for Shikimate and Aromatic Amino Acids in Arabidopsis thaliana 2010-05-17
_[8] 논문 Glyphosate has limited short-term effects on commensal bacterial community composition in the gut environment due to sufficient aromatic amino acid levels https://pure.au.dk/w[...] 2018-02
_[9] 논문 Lessons learned regarding symptoms of tryptophan deficiency and excess from animal requirement studies 2012-12
_[10] 논문 High dietary intake of aromatic amino acids increases risk of hypertension 2018-01
_[11] 논문 Protein tryptophan accessibility studied by fluorescence quenching 2002-05-01
_[12] 논문 Biological Macromolecules: UV‐visible Spectrophotometry http://www.life.illi[...] John Wiley & Sons Ltd 2021-04-02
_[13] 웹인용 Peptide and Amino Acid Quantification Using UV Fluorescence in Synergy HT Multi-Mode Microplate Reader {{!}} April 18, 2003 https://www.biotek.c[...] 2020-03-23
_[14] 논문 A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals 2018
_[15] 논문 The Biosynthetic Pathways for Shikimate and Aromatic Amino Acids in Arabidopsis thaliana 2010-05-17
_[16] 논문 Glyphosate has limited short-term effects on commensal bacterial community composition in the gut environment due to sufficient aromatic amino acid levels 2018-02
_[17] 논문 Editorial: Aromatic Amino Acid Metabolism 2019-04-10
_[18] 논문 Lessons learned regarding symptoms of tryptophan deficiency and excess from animal requirement studies https://academic.oup[...] 2012-12
_[19] 논문 High dietary intake of aromatic amino acids increases risk of hypertension 2018-01